Colchicine Side Effects

Colchicine side effects can prevent this gout medicine being used for pain relief.

Investigations leading to 2010 licensing of colchicine as Colcrys in the USA, have shown that some side-effects are due to the way colchicine has been prescribed in the past. Specifically, those gout studies found that the dose of colchicine was too high in many cases.

This colchicine side effects page covers:

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Foods High In Uric Acid And Purines

Foods high in uric acid and purines form the conclusion of the High Purine Foods study, which is described below. This concludes the study: Purine-Rich Foods, Dairy and Protein Intake, and the Risk of Gout in Men.

Your GoutPal Update

I flagged this article for review as part of my project to make this website easier for all gout sufferers. Therefore, I must make it clear that:

  1. This article is aimed at Gout Dieters. Specifically, gout sufferers who are actively monitoring the effects of their diet changes on their uric acid levels. Otherwise, gout sufferers interested in food should start at GoutPal Plan for Gout Foodies.
  2. Gout Dieters should seek high-protein, low-purine foods. But, they must recognize that vegetable purines do not raise uric acid. Because not all foods high in purines can be described as foods high in uric acid.
  3. Individual high protein foods from animals should not be omitted from your diet simply because they are high in purines. Because Gout Dieters must consider total diet and all factors that affect uric acid levels. Especially purine-rich flesh from overweight bodies.

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Thumb Tophi – Worst Symptom of Thumb Gout

Thumb tophi join the collection of lumps on the hand for victims of tophaceous gout.

As you can see from the photograph below, a thumb tophus can be particularly debilitating if it stops you gripping effectively.

The one shown below is not the worst I’ve seen, but bad enough to make you think twice about leaving your uric acid level above 5mg/dL.

Unfortunately, we do not have a corresponding photograph of the thumb after treatment, but almost all similar case studies show that the tophi dissolve if uric acid is maintained at a suitably low level. If you use the search boxes near the top and bottom of each page to search for lower faster, you will see that aiming for low uric acid is always a good idea when tophi are present.

Thumb Tophi Photograph

Thumb Tophi with Gout Crystals

Thumb Tophi Information

The photograph is one of a series of seven gout pictures from “A Photo Essay of Gouty Arthritis” in Consultant Live[1]. As this is not a regular gout case study, we do not have all the background. I have paraphrased the description of the photograph below, and you can see the original text if you click the photograph.

The thumb of a 70-year-old man shows a white patch surrounded by red inflammation.

The thumb was lanced, and fluid collected, which was analyzed under a microscope, revealing crystals. The crystals split polarizing light in a way that identified them as uric acid crystals. This confirmed a diagnosis of gout.

Results of tests showed a uric acid level of 8.5 mg/dL (0.51 mmol/L) in the blood. The original description refers to a normal range, which is meaningless. You will find information about why this is meaningless if you search for normal uric acid in the search box above or below.

Gout appears first in a single joint, for most gout patients. The essay mentions 70%, but there is no reference for this. Gout involving multiple joints is seen occasionally. This case, where gout is diagnosed despite no swollen joints, is rare.

Thumb Tophi: Next Steps

In this example, the patch of gout crystals is very clear, presumably due to skin bursting at some point. Often, the tophi show as lumps of varying size. If you have unusual growths on your thumbs, you should consult your doctor immediately. You do not have to become a Gout Victim. Also, see more facts for Gout Victims.

Leave Thumb Tophi to browse other Tophi pages.


Thumb Tophi References

  1. Original from Consultant Live article/10162/2103463. Now renamed Patient Care Online. Flagged for review to present PDF file.


Thumb Tophi Document Change History

Thumb Tophi Document Change HistoryTo read the document change history, click the GoutPal History image on the right.

Do you have suggestions for improving Thumb Tophi? Then, please add your idea to GoutPal’s Suggestion Box. Or, send the Feedback Form, below.

Greek Yogurt and Gout

Greek Yogurt and Gout explains links between Greek yogurt, gout, and uric acid. Specifically, I show how Greek yogurt can be good for gout. But only if you eat it in the right way.

Greek Yogurt and Gout Audience

I wrote Greek Yogurt and Gout for GoutPal Foodies. GoutPal Foodies are gout sufferers who want to eat better gout foods. But, they do not have a healthy eating plan. So, I explain how Greek Yogurt might help gout sufferers. But, only if you incorporate it into a healthy gout foundation diet.

Are you unsure which type of gout sufferer you are? Then, before you read this article, go to Questions for Gout Sufferers.

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Is Gout Massage A Bad Treatment Of Gout?

One of the most popular gout topics is massage and gout.

It started with a forum member asking:

A couple times I have massaged the toe joint and it felt like perhaps I was able to break up the crystals a bit. Not sure if that can really happen or if I imagined it. So, my questions are: 1) can you really break down the crystals by manually massaging the joint? 2) if so, should you? Would that help break it down and assist in the process? Or, is it doing more harm than good?

Inevitably, as forum discussions tend to do, there is talk of supporting the gout massage with hot baths, which in turn leads to a discussion of what to put in the bathwater. But this misses the fundamental question: is massage good gout relief, or will massaging gout cause more problems?
Click to discover the dangers of misunderstanding gout and massage

Relief From Stubborn Gout Pain

In my gout pain relief pages, I explain the best approach to gout pain.

The main difficulty with stubborn gout pain is, it rarely responds to a simple treatment. Usually, you need a combination of more than one pain-relieving drug. Often these combinations need to include general painkillers that are not specifically for gout.

Recently, I was asked about combining indomethacin with colchicine for relieving stubborn gout pain.

There are thousands of different combinations that work.

The secret is finding the right combination that suits you.

Colchicine For Stubborn Gout Pain Relief

Gout pain, as I explain in the Uric Acid guidelines, is a result of the immune reaction to invading uric acid crystals. When the immune system becomes overwhelmed, it calls in reinforcements, and this process is at the heart of the agony we experience during an acute gout flare.

Colchicine, sold as Colcrys in America, is very effective when it is taken early enough. That is why doctors advise you to take it at the first sign of a gout flare. The main purpose of colchicine is to prevent, or limit, gout flares when you take uric acid lowering gout medications.

Colchicine works to prevent gout pain, or prevent it getting worse, by slowing your immune system. White blood cells are restricted from growing, and this limits the inflammation that is part of that process.
See why you may need more than colchicine for stubborn gout pain

How Long does Gout last in Big Toe?

How Long does Gout last in Big Toe looks at gout duration in the big toe. Also, I compare this with gout duration in other parts of the body. But, more importantly, what can we do to reduce gout duration?

Gout in Big Toe Audience

I wrote How Long does Gout last in Big Toe for gout sufferers who want to understand gout pain in different joints. In particular, you will be interested in ways to reduce the length of gout attacks. But, in this article, I am not looking at gout medications that reduce pain. So, if you are looking for gout pain medications, please search using the gout search box near the top of each page.

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