Anti-Inflammatory Gout Cure Brings Pain Relief

The gout cure you look for first is one that will relieve the agony.

Though it is vital, in the long term, to control uric acid, those treatments will not give the immediate gout pain relief that you need.

Gout Cure List
Colchicine
Ibuprofen
Indomethacin

Whilst you wait for your uric acid treatment to get you to safe levels, you can look to the pain relieving treatments listed here.

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Relief From Stubborn Gout Pain

In my gout pain relief pages, I explain the best approach to gout pain.

The main difficulty with stubborn gout pain is, it rarely responds to a simple treatment. Usually, you need a combination of more than one pain-relieving drug. Often these combinations need to include general painkillers that are not specifically for gout.

Recently, I was asked about combining indomethacin with colchicine for relieving stubborn gout pain.

There are thousands of different combinations that work.

The secret is finding the right combination that suits you.

Colchicine For Stubborn Gout Pain Relief

Gout pain, as I explain in the Uric Acid guidelines, is a result of the immune reaction to invading uric acid crystals. When the immune system becomes overwhelmed, it calls in reinforcements, and this process is at the heart of the agony we experience during an acute gout flare.

Colchicine, sold as Colcrys in America, is very effective when it is taken early enough. That is why doctors advise you to take it at the first sign of a gout flare. The main purpose of colchicine is to prevent, or limit, gout flares when you take uric acid lowering gout medications.

Colchicine works to prevent gout pain, or prevent it getting worse, by slowing your immune system. White blood cells are restricted from growing, and this limits the inflammation that is part of that process.
See why you may need more than colchicine for stubborn gout pain

Start Allopurinol Quickly, But Carefully

Surprising allopurinol news – it’s OK to start today even if you have an active gout flare.

Let me explain the new study into starting allopurinol, then you can see how it applies to you.

For a long time, rheumatologists have recommended against starting allopurinol if you have are experiencing a gout flare. They fear that allopurinol will make the flare worse, so it is better to wait until it has subsided before starting allopurinol.

This has always puzzled me. I know from years of gout pain experience, that gout pain can be controlled with the right pain relief combination. Given that, I have never understood why there should be a delay. New research agrees with me.

Continue to read the Starting Allopurinol Study

Indomethacin & Gout

Though not gout specific, indomethacin & gout are closely linked, as it is very often prescribed to relieve gouty arthritis pain.

Here I look at what little evidence there is concerning indomethacin as a specific anti-inflammatory gout cure.

I’ve searched for information to assess the suitability, or otherwise, of indomethacin for gout, but there is little reliable, conclusive proof that it is any better or worse than other pain relief.

Several studies compare indomethacin with various other pain-relieving drugs. Unfortunately, most of these alternatives are not approved at all, or not approved for gout. There are a couple of Hong Kong studies that directly compare indomethacin (or indomethacin combinations) with prednisolone (or prednisolone combinations).

Gout Medication Indomethacin Pack ShotNow, prednisolone is a steroid that works by reducing gout inflammation. Some doctors swear by it, whilst others try to avoid it. Personally, I’m very wary of the side effects. I’d love to hear from you if you have happily used steroids for gout, so please share your experience in the gout forum.

Meanwhile, back to the aforementioned comparisons.

Indomethacin & Gout Investigations

One, “Oral prednisolone is more cost-effective than oral indomethacin for treating patients with acute gout-like arthritis” is a little unclear to me, as it appears to report US$ and GB£ cost savings as well as HK$. It appears to simply convert Hong Kong cost savings into other currency equivalents, but only costs calculated at USA and UK locations would be relevant. Forgive me if I have misunderstood the summary (I do not have access to the full report). However, I also have serious misgivings where treatment is justified on costs alone.

A linked study, “Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis: a double-blind, randomized, controlled trial,” attempts to compare the treatments on medical grounds. However, I feel that it gives no credence to fears of prednisolone side-effects. The recommendation seems mainly based on the fact that prednisolone causes fewer stomach problems than indomethacin, disregarding other problems that prednisolone may cause, especially if taken over a long period.

Indomethacin & Gout Conclusions

This is definitely a case where you must discuss any concerns you have about indomethacin and gout with your doctor. If you are not sure what to ask, or do not understand your doctors response, please discuss your problems and experiences in the gout treatment forum.

Leave Indomethacin & Gout to browse other indomethacin pages.

Indometacin

Indometacin (often spelled indomethacin) is a Non-Steroidal Anti-Inflammatory (NSAID) drug commonly prescribed for acute gout pain.

As with all NSAIDs, it is not suitable for long term use, so it is best used by gout sufferers as a short term measure to help them survive the early, often painful, stages of uric acid reduction treatments.

What Is Indometacin?

Indometacin reduces inflammatory pain by reducing hormones that cause that pain, inflammation, or stiffness. It works by inhibiting prostaglandins, which are the hormones that cause these symptoms. Specifically, this is classed as COX-2 inhibition. However prostaglandins are also responsible for reducing injury to stomach linings, which is why NSAIDs are not suitable for anyone with digestive problems.

Indometacin was discovered in 1963 and the U.S. Food and Drug Administration granted approval in 1965.

Subsequent investigations into COX-2 inhibitors have caused the FDA to insist on warnings of heart and stroke risks, which rise with prolonged use.

Indomethacin Or Indometacin?

Though most new drugs are covered by brand names, older drugs, or where license has expired, are known as generic drugs, or simply, generics. Generics are subject to naming conventions to avoid confusion, unfortunately, confusion still reigns, especially in the multi-national world, as their are two lists.

In the USA, all generics are listed by the United States Adopted Names Council of the American Medical Association. Their list is known as USAN, and this is the preferred list at GoutPal.com, as the majority of visitors are based in USA. The USAN spelling is indomethacin, but I’m including the alternate spelling on this page, as it is the World Health Organization (WHO) standard.

In the UK, there used to be a British Approved Name (BAN) list, which was very similar to USAN. The UK has now adopted the WHO standard, which is called International Nonproprietary Names (INN). On this list, the correct spelling is indometacin. This spelling may also be included on other pages here, especially when I am quoting research work, which is increasingly adopting the INN spellings in most countries.

How Is Indometacin Taken?

Indometacin is available as:

  • Standard Tablet
  • Slow Release Tablet
  • Capsule
  • Suppository

Dosage will be determined by your doctor, and should never be exceeded. For maximum pain relief, your doctor may prescribe co-administration with other gout pain relief.

Indometacin: Next Steps

Please see the rest of the indometacin reference information.

Indomethacin and Gout Pain Relief

Please see Indomethacin guidelines for latest information on indomethacin & gout.

Indomethacin (often sold under the Indocin brand name) is the most commonly prescribed anti-inflammatory drug for reducing painful gout swelling.

It acts upon the hormones that cause swelling and pain.

It is available as regular capsules, sustained release capsules, liquid and suppositories. Recently, it has become available as indomethacin ointment.

You may need to take capsules or liquid with milk or food to reduce the chance of stomach upset.

Do not open sustained release (SR) capsules – they must be taken whole.

Over-the-counter medicines can contain similar anti-inflammatory drugs, e.g. Ibuprofen, aspirin.
Do not take any other medication alongside indomethacin without consulting your doctor.

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Is Your Indomethacin Dosing Safe?

I am reviewing indomethacin dosing following my recent review of colchicine.

Though both are used to combat gout pain during acute attacks, they work very differently. They have different effects on pain, and different side effects on the rest of the body.

I cover the individual effects in the relevant guidelines, but today I want to focus on common safety issues.

I am using indomethacin as an example of a Non-Steroidal Anti-Inflammatory Drug (NSAID). Everything I say about indomethacin applies to any NSAID, but I have selected indomethacin as one of the most prescribed drugs for gout pain.

Here is a list of NSAIDs. New ones may have been added since this was prepared, so please check the labels of all medicines you are taking.

Continue reading about safe indomethacin dosing