Colchicine Side Effects

Colchicine side effects can prevent this gout medicine being used for pain relief.

Investigations leading to 2010 licensing of colchicine as Colcrys in the USA, have shown that some side-effects are due to the way colchicine has been prescribed in the past. Specifically, those gout studies found that the dose of colchicine was too high in many cases.

This colchicine side effects page covers:

continue reading Colchicine Side Effects

Relief From Stubborn Gout Pain

In my gout pain relief pages, I explain the best approach to gout pain.

The main difficulty with stubborn gout pain is, it rarely responds to a simple treatment. Usually, you need a combination of more than one pain-relieving drug. Often these combinations need to include general painkillers that are not specifically for gout.

Recently, I was asked about combining indomethacin with colchicine for relieving stubborn gout pain.

There are thousands of different combinations that work.

The secret is finding the right combination that suits you.

Colchicine For Stubborn Gout Pain Relief

Gout pain, as I explain in the Uric Acid guidelines, is a result of the immune reaction to invading uric acid crystals. When the immune system becomes overwhelmed, it calls in reinforcements, and this process is at the heart of the agony we experience during an acute gout flare.

Colchicine, sold as Colcrys in America, is very effective when it is taken early enough. That is why doctors advise you to take it at the first sign of a gout flare. The main purpose of colchicine is to prevent, or limit, gout flares when you take uric acid lowering gout medications.

Colchicine works to prevent gout pain, or prevent it getting worse, by slowing your immune system. White blood cells are restricted from growing, and this limits the inflammation that is part of that process.
See why you may need more than colchicine for stubborn gout pain

GoutPal Plan for Gout Patients

Do you want medical gout treatment to lower your uric acid?
Then, GoutPal Plan for Gout Patients is for you.
It is a 7 step plan for lowering uric acid.
Especially, helpful for choosing the best medicines to suit your unique situation.

GoutPal Plan for Gout Patients Audience

I wrote GoutPal Plan for Gout Patients for gout sufferers who want to use medical uric acid lowering therapies. If you are not sure which type of gout sufferer you are, go to Questions for Gout Sufferers.

continue reading GoutPal Plan for Gout Patients

Gout Medications To Avoid Gout By Lower Uric Acid

To avoid gout, your treatment has to permanently lower uric acid down to safe levels.

Please note that this page, and the associated medications pages, are about gout treatment that will allow you to avoid gout for the rest of your life. It is not about medications that you should avoid. For that, you should see What Causes Gout? in the Gout Symptoms, Causes, & Diagnosis guidelines.

Also, note that this gout medications page is not about what you eat. For ways of avoiding dietary causes of gout, please see Foods To Avoid With Gout and Gout Foods To Avoid in the Gout Diet Including Food, Drink & Lifestyle guidelines.

There are many urate-lowering therapies, with more in development. You need to choose the right one, and you might need pain relief for the weeks or months it takes to lower uric acid to a safe level.

Whichever gout cure you choose, make sure it keeps your uric acid at 5mg/dL (0.30mmol/L), or below.

continue reading Gout Medications To Avoid Gout By Lower Uric Acid

Colcrys (Colchicine)

Colcrys (Colchicine) guidelines start here. There are links to all the main Colcrys pages below, and here are the latest additions:

Colchicine is a powerful weapon in the fight against gout pain, but it is not without critics.

In America, controversy rages about the decision to remove its generic status. But, politics and financial considerations aside, gout sufferers need to know how colchicine can help their gout.

Here we look at how colchicine (sold as Colcrys in the United States) can help gout patients, along with its drawbacks and advantages.

Colchicine As An Anti-Inflammatory

Though I include colchicine in the anti-inflammatory drugs that cure gout pain, it is not a true anti-inflammatory, and it does not directly act on gout pain.

Colchicine stops inflammation getting worse. That is why it is important to take the first tablet at the first sign of a gout attack. If you leave it too late, and inflammation has already started to subside naturally, there is no point taking colchicine.

Colchicine will not reduce inflammation, but it does allow natural anti-inflammatories in your body to reduce inflammation over a few hours. The exact time varies from person to person, and also depends on the severity of the gout attack. In severe gout attacks, it can take two or three days for inflammation to reduce.

If you do not feel less pain in an hour, you can take a second colchicine, but no more than 2 per day. You can also reduce inflammation with NSAIDs (naproxen, ibuprofen, etc), and you can block pain with analgesics. Your pharmacist and doctor can advise you about safe combinations to support colchicine. My Stop Gout program can help you create your own personal treatment plan, including how to select the right colchicine support package to maximize gout pain relief.

Colchicine & Gout Introduction

Due to the large amount of information on colchicine & gout, I have created different pages to cover different aspects:

  • What Is Colchicine?
  • How Does Colchicine Help Gout?
  • What are the Side Effects of Colchicine?
  • How Much Colchicine Is Required?
  • Other Aspects Of Colchicine (including spelling)

What Is Colchicine, and How Does Colchicine Help Gout?

Colchicine for gout is a great way to stop gout pain, but unsafe the wrong way. Longterm, or without uric acid control, Colcrys is dangerous. See safe practice at Colchicine For Gout.

What are the Side Effects of Colchicne?

Colchicine side effects worry many gout patients. Is it a blissful gout pain reliever or dangerous poison? See how to balance risks safely. Take care with gout, and read the colchicine side effects information.

How Much Colchicine Is Required?

Colcrys (colchicine) Dosage
Colcrys (colchicine) dosage has been confusing for many years. Now we know exactly what to take. See what to do if you are still in pain.

Other Aspects Of Colchicine

Colchicine is also available combined with probenecid, marketed as Colbenemid and Proben-C

Colchicine Spelling

Like many medicines, colchicine is often misspelled. Though spelling is often overrated, it pays to take extra care with medicines, as a misunderstanding might cause treatment problems in the unlikely event of a similar sounding drug being taken mistakenly.

In the list below, I have included brand names, where the active ingredient is colchicine alone. When buying medicine, it is usually best to use the generic name rather than a brand name, unless additional active ingredients make the gout medicine more useful to you.


Incorrect spelling of the brand Colcrys.


First i replaced with a, second i replaced with e.


first i replaced with a.


First i replaced with e.


ic replaced with es.


Extra h after third c.


This is the correct spelling of the gout medicine that is used to relieve gout pain by reducing inflammation. Full details can be found in the colchicine pages in the Anti-Inflammatory Gout Cure part of the Gout Treatments Section.


Colchimax is a brand name for colchicine in parts of Europe.


Missing ic.


First i replaced with o.


Incorrect spelling of the brand Colcrys.


Incorrect spelling of the Colcrys brand.


Incorrect spelling of the Colcrys brand


Colcrys is the brand name for colchicine in the USA.


Colgout is a brand of colchicine in Australia.


chi replaced with tra.


chic replaced with tras.

If you are aware of other alternative spellings, or if you have any questions or opinions about colchicine, please discuss them in the gout remedies forum.

Leave Colchicine to browse other anti-inflammatory gout cure pages

Colchicine Document Change History

Colchicine Document Change HistoryTo read the document change history, click the GoutPal History image on the right.

Do you have suggestions for improving Colchicine? Then, please add your idea to GoutPal’s Suggestion Box. Or, send the Feedback Form, below.

Gout & Ibuprofen Side Effects

Ibuprofen side effects stop some gout patients using this very popular anti-inflammatory drug.

Most side effects relate to stomach problems.
Now, gel or cream formulations overcome some of these ibuprofen side effects.

Ibuprofen (sometimes called ibuprofin or ibuprophen*) is in the NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) category.
These act upon the hormones that cause swelling and pain.

You take ibuprofen tablets or liquid orally. Or rub gel or cream into the skin.

I first took ibuprofen for gout before I knew I had it.
I had tablets prescribed in hospital when I was waiting to be tested and diagnosed.
Nurses warned me that it might upset my stomach, but I was fine.
You might need to take tablets or liquid with milk or food to reduce the chance of stomach upset.

Now that gel is available, you can reduce the risk of stomach related ibuprofen side effects. You apply the gel around the area of swelling and gently massage it into the skin. Note that you absorb ibuprofen into the bloodstream, so skin application does not reduce the risk of other ibuprofen side effects (allergy or kidney problems). The good news is you can usually gain relief with a smaller dosage when it is applied to the affected area.

Read more about Ibuprofen Side Effects

Probenecid Side Effects for Gout Patients

Probenecid side effects are rare.

But you must take some precautions to avoid common problems.

Before you look at side effects of probenecid, you should understand how probenecid works. It was originally developed to improve the effectiveness of penicillin by restricting its excretion through the kidneys. It has significant effects on many compounds by either restricting or encouraging excretion rates in urine. If you are taking any other medications or supplements, including herbal preparations, you must tell your doctor. This will help your doctor determine if the side-effects are purely down to probenecid, or if the other compounds are involved. If they are, you can often overcome side-effects by adjusting the dose of the other medicine.

Probenecid Precautions


On the main probenecid page, I described how the dose might be accompanied by alkalizing agents or alkalizing diet. But be sure to advise your doctor if you are taking precautions against acid urine. Then your acid-base balance can be monitored. Failure to alkalize might lead to the following side-effects:

  • Hematuria – red blood cells in the urine. These are not usually visible, but you should confirm that your doctor will include this in your urine tests.
  • Costovertebral pain – pain in the joints between spine and ribs.
  • Renal colic – sudden, sharp kidney pains, which could be associated with …
  • Formation of uric acid stones

Other Health Conditions

Use with caution if you have a history of peptic ulcer.

If you have kidney impairment, you may need a higher dosage, though if the impairment is chronic (glomerular filtration rate is 30 mL/minute or less), then probenecid is unlikely to be effective. Do not take penicillin with probenecid if you have kidney problems.

Probenecid might affect tests for other health conditions as it causes reducing substances in the urine. This might cause a suspicion of diabetes, but this can be discounted with a specific test for glucose.

Probenecid Side Effects

Before I list probenecid side effects, I should point out a couple of observations based on discussions with several gout sufferers in the gout forums.

  • In these notes about probenecid, and in several other pages about gout medications to lower uric acid, I explain that the medicine can cause gout flares as old crystals dissolve. This is no different to the reaction to new crystals forming, but it can be more widespread. Normally, we only notice pain and inflammation in one or two joints. The new crystal attacks are usually accompanied by feverish, flu-like symptoms, and itchy skin, but the pain often masks these. When the reaction to old crystals is less intense and more widespread, we may not recognize it as gout. You must persevere with this – it gets easier with each passing week.
  • Starting new medications, worrying about how they will work, and other aspects of treating your gout can cause anxiety. Physical symptoms of anxiety are (with thanks to NetDoctor):
    • Racing heartbeat (palpitations)
    • Breathing fast, feeling short of breath or finding it hard to ‘get breath’
    • Chest tightness
    • Dry mouth, butterflies in the stomach, feeling sick
    • An urge to pass urine
    • Tremor
    • Sweating

    Try to stay calm and trust the process – you’ll soon be enjoying your gout freedom.

Side effects, or adverse reactions to probenecid, starting with the most severe, include:

Central Nervous System:
Headache, dizziness.
Precipitation of acute gouty arthritis.
Hepatic necrosis (localized liver damage), vomiting, nausea, anorexia, sore gums.
Nephrotic syndrome (non-specific kidney damage), uric acid stones with or without hematuria, renal colic, costovertebral pain, urinary frequency.
Anaphylaxis (severe allergic reaction), fever, urticaria (rash/hives), pruritus (itch).
Aplastic anemia (shortage of red blood cells from bone marrow), leukopenia (shortage of white blood cells), hemolytic anemia (premature death of red blood cells) which can sometimes be related to genetic deficiency of glucose -6- phosphate dehydrogenase in red blood cells, anemia (shortage of red blood cells with unknown cause).
dermatitis, alopecia, flushing.

Probenecid Side-Effects and Interactions
Probenecid Side-Effects and Interactions

Probenecid Spellings

Like many medicines, probenecid is often misspelled. Though spelling is often overrated, it pays to take extra care with medicines, as a misunderstanding might cause treatment problems in the unlikely event of a similar sounding drug being taken mistakenly.

In the list below, I have included brand names, where the active ingredient is probenecid alone (it is frequently mixed with colchicine). When buying medicine, it is usually best to use the generic name rather than a brand name, unless additional active ingredients make the gout medicine more useful to you.


Second e changed to a.


Missing second e.


This is the correct spelling of the uricosuric drug probenecid, which encourages uric acid excretion in those gout patients who are under-excreters.

Probenecid Brands

Common brand names include: Benemid; Probecid; Benecid; Benuryl; Pro-Cid


ecid changed to esid.


Second e changed to i.


ene changed to ini.

If you are aware of other alternative spellings or common brand names, please share them on the gout resources forum. Though I am happy to discuss all aspects of probenecid side effects, I cannot give you specific personal advice. If you experience adverse reactions, you must consult your doctor or pharmacist immediately.

Leave Probenecid Side Effects to browse other aspects of Gout Treatment.