Herbal XOIs Green Tea & Resveratrol explains how 2 herbal Xanthine Oxidase Inhibitors (XOIs) can lower uric acid. Specifically, it describes studies of green tea leaf extract, and resveratrol.
Herbal XOIs Green Tea & Resveratrol Audience
Firstly, Herbal XOIs Green Tea & Resveratrol is aimed at Gout Herbalists. So, you should think about what type of gout sufferer you are. But, if you’re unsure, please read Questions for Gout Sufferers before reading this.
Herbal XOIs Can Help Reduce Uric Acid
Hyperuricemia is the hallmark of gout. Pathogenic mechanisms of hyperuricemia include uric acid overproduction in the liver or under-excretion in the kidney. Current anti-hyperuricemic agents include xanthine oxidase inhibitors (XOI) in which allopurinol is the most often prescribed. However, many gout sufferers have side effects from allopurinol. So the search for natural agents has pushed many to try products other than the more commonly used pharmaceutical medicines.
Herbal XOIs can be part of the gout treatment regimen. There are two very potent and safe agents that have XOI effects, green tea leaf extract and Resveratrol from Japanese Knotweed root. If you are unfamiliar with the XOI term, I usually refer to them as Uric Acid Blockers.
Green tea contains a high level of catechins, in which Epigallocatechin gallate (EGCG) is the most abundant compound among other types of catechins. Their antioxidant effect contributes to various potential health benefits of green tea. Several in vitro studies have found that green tea inhibits xanthine oxidase activity and subsequently uric acid production. It is interesting to note that the FDA has approved human clinical trials in the United States that will study the effects of green tea leaf extract on gout.
Resveratrol from Japanese Knotweed root, an exceptionally potent polyphenol compound, has been shown in vitro to be capable of directly inhibiting xanthine oxidase activity and thus block the overproduction of uric acid .
It is important when considering natural agents to reduce uric acid, that one considers both uricosuric and xanthine oxidase inhibitors.
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