Is Your Gout Hereditary?

Do you wonder why you have gout?

Is it bad diet, bad lifestyle choices or just bad luck?

There can be a host of reasons why we get gout, and I reviewed them in What Causes Gout? Now, I want to focus in more detail on the genetics of gout.

Hereditary Gout Study

There is an interesting study of the hereditary aspects of gout. Tony Merriman and Nicola Dalbeth have investigated how different genes are associated with different aspects of gout and high uric acid.[1]

Hereditary Gout Checkpoints

This study identifies key checkpoints for gout:

Uric Acid Production
Though there are many causes of excess uric acid production, as described in the gout symptoms guidelines, this gout study notes that genetic causes are rare. The hereditary causes of excess uric acid production are:

rare genetic causes such as hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency and PRPP synthetase (PRS) superactivity

Uric Acid Excretion
The report identifies 6 genes that limit uric acid excretion in different ways. The most important gene, SLC2A9 accounts for less than 5% of effects on people with Caucasian ancestry. However other genes with smaller effects contribute to the personal reduction of uric acid excretion.
Uric Acid Crystal Deposits
Not all people with high uric acid (hyperuricemia) develop gout. The authors note research into other factors that can trigger crystals to form, and suggest some of these may have genetic links.
Inflammation
The pathway that leads from uric acid to gout pain is very complicated. It involves the immune system, yet people vary in their immune response to uric acid crystals. Also, inflammation resolves much quicker for some people than others.
Tophi and Bone Erosion
With prolonged exposure to high uric acid, tophi form and spread throughout the body. Again, the rate at which this happens, and the amount of damage, differ significantly from person to person.

For the first two checkpoints, some hereditary links have been confirmed, but the authors note that more research is needed. This is especially the case for the last three checkpoints where personal variations suggest genetic links are likely. Many hereditary factors still need to be investigated, especially with large specific genetic groups.

Gout Genes

Various studies have been carried out on the six genes that affect uric acid excretion. I have summarized the data from the report in this picture:

What to do about Hereditary Gout Symptoms

Though it is interesting to move away from the common focus of gout diet, we know that here is nothing we can do to change our genes.

What you must do, if there is any doubt about your gout diagnosis, is to study the gout symptoms guidelines first. Once you have a confirmed gout diagnosis from your doctor, you can discuss gout treatment with him. Once you have a gout treatment plan that suits your personal situation, you might be able to improve your diet to boost your treatment plan.

Leave Is Your Gout Hereditary? to browse the Gout Symptoms guidelines


Hereditary Gout References

Title:
The genetic basis of hyperuricaemia and gout.
Authors:
Merriman TR, Dalbeth N.
Published:
Joint Bone Spine. 2011 Jan;78(1):35-40
Please Share This Page

What do you think about this page?

Did this page help you? If yes, please consider a small donation. Your donations help keep GoutPal's gout support services free for everyone. Please click to donate:

If not, please tell me how I can improve it to help you more.

Please note that my Feedback Form does not yet work on the current version of this website. So please send your feedback:

More Stories

Medical Disclaimer: The pupose of GoutPal is to provide jargon-free explanations of medical gout-related terms and procedures. Because gout sufferers need to know what questions to ask their doctor. Also, you need to understand what your doctor tells you. So this website explains gout science. But it is definitely NOT a substitute for medical advice.

Information on this website is provided by a fellow gout sufferer (Keith Taylor) with an accountant's precision for accurate data. But no medical qualifications. So you must seek professional medical advice about gout and any other health matters.

Google Gout

Type your question, or gout topic, in the search box. Or see Better Desktop Gout Search.