Natural Uric Acid Inhibitors: Can They Work?

Natural uric acid inhibitors are very popular with gout sufferers.

Many want to avoid pharmaceutical methods for uric acid lowering. So, they look to the world of herbal gout medicine for solutions. We recently discussed chanca piedra for gout, in the gout forum. I voiced my concerns about the validity of herbal gout medicine. I guess it’s one of those topics where I have mixed feelings. My heart says “got to be good for gout.” Yet, my head says “this is dangerous gout exploitation.”

Natural Uric Acid Inhibitors Introduction

I love the idea of natural gout treatments. However, the reality is that gout sufferers often get misled by false claims. At best this gives a false sense of security. At worst, it delays effective treatment. Delays prolong the agony. Delays increase joint destruction from excess uric acid.

Having said all that, I will always be interested in herbal gout medicine. As with all other gout treatment, everything depends on the individual. What suits one gout sufferer might be wrong for another. There is absolutely no reason why you should not try herbal gout medicines. But, you may need some help and guidance.

All gout medicines have one or two functions. They might help relieve gout pain. They might help lower uric acid. A few do both. There are two types of uric acid lowering medicines. Some encourage uric acid excretion. Some discourage uric acid production. Here, I’m looking at this last group, particularly natural uric acid inhibitors.

What are Natural Uric Acid Inhibitors?

Natural uric acid inhibitors are plants that block uric acid production in your body. Uric acid is produced when an enzyme, xanthine oxidase (XO), breaks down purines. Purines might come from flesh that you eat or from your own flesh. If xanthine oxidase is blocked, then uric acid production is reduced. That is how allopurinol and Uloric work.

Beyond Chanca Piedra for Uric Acid

During my research into chanca piedra, I learned a new term: phytomedicine aka phytotherapy. This relates to the medical application of phytochemicals. Phytochemicals are chemical compounds that occur naturally in plants. These work in the same way as allopurinol and Uloric. There are several compounds that are natural uric acid inhibitors. Would you like to see a list?

Natural Uric Acid Inhibitors Chart

One gout study has listed 30 plants that contain natural uric acid inhibitors[1]. So here is my version of their chart with these plants in order of greatest potency:

Plant name Local name Percent of XO inhibition (50-100µg/mL) IC50 (µg/mL) Part of plant used
Flaxinus, Ash 48-96% 28-53 Bark
Chrysanthemum flower 34-95% 24-91 Flower
Ligusticum 17-94% 34 Rhizome
Knotweed 12-94% 38 Rhizome
Piper 11-94% 28 Stem
Gypsywort, Bugleweed 39-93% 26-79 Leaf
White mulberry 18-93% 57 Twig
Angelica root head 18-93% 40 Root
Glechoma 16-91% 48 Whole plant
Angelica root 40-90% NR Root
Sweet gum fruit 48-89% 33-66 Whole plant
Prickly ivy’s, catbriers 18-89% 62 Rhizome
Scutellaria, Barbal skull cap 31-87% 62 Whole plant
Harlequin glory bower 12-86% 65 Leaf
Strychnine tree 38.7-82% 6.8-32 Leaf
Safflower 23-81% 64 Fruit
Tiger claw 17-79% 70 Bark
Tondi 40-77% 21-32 Leaf
Chaste tree 6.2-66% 76-88 Leaf
Astragalus root 12-64% 85 Root
Selfheal spike 27-63% 86 Whole plant
Angel or Devil’s trumpet 9.4-62% 77 Leaf
Lycopodium tuber 13-58% 94 Whole plant
Rhubarb rhizome 17-57% 101 Rhizome
Salvia root 27-56% 96 Root
Plantago 26-56% 98-103 Seed, Aerial
Cuscuta seed 23-55% 53 Seed
Orange 27-51% 98 Fruit shell
Kochia fruit 24-51% 116 Seed
Licorice root 24-49% NR Root

That report also lists 6 additional plants that might have use as anti-gout agents:

  1. Gloriosa superba Linn – potential source of colchicine
  2. Erythrina indica Lam – another natural uric acid inhibitor
  3. Citrus aurantium Linn, Citrus limetta W. and A. and Citrus limon (Linn) Burm – more natural uric acid inhibitors
  4. Tephrosia purpurea (Linn.) Pers – anti-inflammatory and natural uric acid inhibitor
  5. Capparis decidua Edgew – described as having “antigout” properties
  6. Polyalthia longifolia (Sonn.) Thwaites – natural uric acid inhibitor, and potential use in preventing gout complications associated with chronic diabetes

Your Natural Uric Acid Inhibitors

In the gout forum, I’ve voiced my personal concerns about natural uric acid inhibitors. How can we ascertain correct dosage, and how can we be sure that dosage is safe?

But we all know that gout treatment has to be personal. It may well be that one of the natural uric acid inhibitors from my chart is perfect for you. The best way to find out is to join the discussion I mentioned earlier. Better still, start your own gout topic about your experiences of, and opinions on, natural uric acid inhibitors.

To make the right choice from natural uric acid inhibitors, you need personal gout treatment plans. My plans require nothing from you but your time. We spend time together, investigating your choices and choosing the right options for you. I’m with you every step of the way to stop your gout permanently. For more information, see my personal gout treatment plans to Stop Gout.

Leave Can Natural Uric Acid Inhibitors Work? to browse Stop Gout treatment plans


Natural Uric Acid Inhibitors References

  1. Kumar, Ajay, and Wamik Azmi. “Phytomedicine: A novel alternative for treatment of gout.” Ann Phys Med 3 (2014): 80-8. Plants to Lower Uric Acid PDF.

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Medical Disclaimer: The pupose of GoutPal is to provide jargon-free explanations of medical gout-related terms and procedures. Because gout sufferers need to know what questions to ask their doctor. Also, you need to understand what your doctor tells you. So this website explains gout science. But it is definitely NOT a substitute for medical advice.

Information on this website is provided by a fellow gout sufferer (Keith Taylor) with an accountant's precision for accurate data. But no medical qualifications. So you must seek professional medical advice about gout and any other health matters.

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