Gout cures come in many forms.

There are:

  • Treatments to lower uric acid and treatments to relieve gout pain.
  • Gout medicines, and alternative remedies.
  • Established therapies, new therapies, and therapies in development.

Whilst reorganizing the Gout Treatment section, and other tidying up tasks, I’m reminded of another form of gout treatment – just stop whatever is causing your gout.

Now, it is not always possible to determine all causes of gout, and I explain some of the difficulties in the Gout Symptoms Section. However, I’ve just re-discovered an interesting report that might give you extra clues, if you take medication for other health conditions.

Diuretics are a well known cause of gout. They are often prescribed for high blood pressure, for which there are often alternatives that do not cause gout.

One hyperuricemia and gout study lists several potential gout-causing drugs[1]. Including:

Mechanism Drug
Increased purine ingestion Pancreatic enzymes (pancreatin, pancrelipase)
Increased uric acid production (cell lysis, catabolic effect, increased WBC production, hemolysis) Cytotoxic chemotherapy (e.g., aldesleukin, asparaginase, busulfan, carboplatin, chlorambucil, cisplatin, cyclophosphamide, cytarabine, daunorubicin, fludarabine, hydroxy-urea, mechlorethamine, melphalan, mercaptopurine, thioguanine, vinblastine,vincristine), didanosine, ethanol, filgrastim, fructose, glucocorticoids, ribavirin/interferon
Reduced renal clearance of urate ACE inhibitors (e.g., lisinopril, ramipril, trandolapril), cyclosporin, diazoxide, diuretics (i.e., acetazolamide, bumetanide, chlorthalidone, ethacrynic acid, furosemide, indapamide, metolazone, thiazides, triamterene), ethambutol, levodopa, pyrazinamide, salicylates (low dose), tacrolimus
Increased urate production & decreased clearance Niacin

The report lists several other drugs, some of which might have alternatives. Even where there are no alternatives, if the medicine at fault is not a permanent requirement, it is good to know that you might be able to stop gout treatments when the other condition is cured.

Whatever your situation, it is always wise to discuss potential side effects and drug interactions with your doctor or pharmacist. As the report concludes:

Gout has been linked to many medications (see Table 3 [additional to table above]). By identifying patients who are at higher risk for hyperuricemia, pharmacists can monitor patients when suspected agents are added to their regimen.

Drugs Causing Hyperuricemia
Drugs Causing Hyperuricemia[2] (click image for list)

Your Drug Induced Hyperuricemia and Gout

Drugs for conditions other than gout are one of the causes secondary gout. So if this affects you, you might be able to switch to alternatives.

Your best approach is to discuss this with your doctor immediately. If there are no alternatives to drugs that cause your secondary gout, you should start a GoutPal Plan for Gout Patients. But also keep your Secondary Gout Plan open for annual review. Because gout-friendly treatments for your other health condition(s) might become available later.

Return from Drug Induced Hyperuricemia and Gout to continue GoutPal Plan for Secondary Gout.


Drug Induced Hyperuricemia and Gout Comments

GoutPal visitor responses and associated research include:

Drug Induced Hyperuricemia Treatment

Gordon asked, “Do you have any more info on lisinopril and ramipril?”

I’m chasing Gordon for some more information about his specific concerns. Then I can help frame my research in the best context for him. In the meantime, I’m looking into recent research for those treatments to see how they induce hyperuricemia. Also, if there are better alternatives for gout sufferers. At the same time, I will expand the information about other gout-inducing treatments. So if you have specific concerns you would like me to include, please use the feedback form below. To get email notification of new articles:

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Drug Induced Hyperuricemia and Gout References

  1. Pearson, Norma Lynn. “Hyperuricemia and Gout: Some Medications can ‘Precipitate’Gout.” Canadian Pharmacists Journal/Revue des Pharmaciens du Canada 139, no. 4 (2006): 62-65.
  2. Saigal, Renu, and Abhishek Agrawal. “Pathogenesis and clinical management of gouty arthritis.” J Assoc Physicians India 63, no. 12 (2015): 56-63.

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