How Gout can Kill You

How Gout can Kill You is my featured image for 21 Ways Gout Can Kill You. So here I list the 21 ways that gout can kill you. Followed by 4 ways that uric acid treatment can help avoid gout fatalities.

How Gout can Kill You image details

The original image is captioned

Possible mechanisms by which uric acid might mediate cardiovascular disease, hypertension, and kidney disease. CAD, coronary artery disease.

First, I took the original image from the gout and heart disease study:
Kanbay, Mehmet, Mark Segal, Baris Afsar, Duk-Hee Kang, Bernardo Rodriguez-Iturbe, and Richard J. Johnson. “The role of uric acid in the pathogenesis of human cardiovascular disease.” Heart (2013): heartjnl-2012.

Then I simplified the text boxes to focus on key causes of organ damage showing risks of disease and failure of kidneys, heart, and brain. So I will show the original text now for those of you interested in medical specifics.

How Gout can Kill You

For each of my added boxes, here is the original text:

High Uric Acid

The report centers on problems with excess uric acid. Medically, this is known as Hyperuricemia. There is no strict definition. But generally, rheumatologists take it to be over 7mg/dL. However, this might depend on personal circumstances. For example, if your job entails prolonged exposure to cold temperatures, then your personal definition of hyperuricemia might be over 5 mg/dL.

Brain Damage

The 4 uric acid risks of stroke and dementia are:

  • 1. Increases risk for stroke.
  • 2. Associated with poorer long-term outcome for stroke.
  • 3. May impair autoregulatory response of the cerebral arterioles.
  • 4. Increases risk for vascular dementia.

Heart Damage

The 5 uric acid causes of artery & heart disease are:

  • 5. Causes endothelial dysfunction.
  • 6. Increases oxidative stress.
  • 7. Causes microvascular disease.
  • 8. Induce vascuar smooth muscle cell proliferation.
  • 9. Causes a reduction in endothelial NO bioavailability.

Heart Disease

The 4 uric acid risks of heart failure are:

  • 10. Causes hypertension.
  • 11. Causes diastolic dysfunction.
  • 12. Associated with increased mortality in congestive heart failure and CAD (Coronary Artery Disease).
  • 13. Associated with cardiac microvascular disease and poor outcome following myocardial infarcation.

Kidney Damage

The 5 uric acid causes of kidney disease are:

  • 14. Causes activation of the renin-angiotensin system.
  • 15. Causes microvascular and inflammatory changes in the kidney.
  • 16. Impair the autoregulatory response of kidney.
  • 17. Causes interstitial macrophage and T-cell infiltration.
  • 18. Causes afferent arteriolopathy (disease of nerve signals from arterial blood vessels in the kidneys).

Kidney Disease

The 3 uric acid risks of kidney failure are:

  • 19. Causes kidney disease progression.
  • 20. Causes kidney allograft dysfunction.
  • 21. May be involved in preeclampsia.

Uric Acid Treatment

The 4 reduced uric acid improvements to brain, heart, and kidneys are:

  1. Decreases blood pressure.
  2. Improves kidney function.
  3. Decreases inflammation.
  4. Improves endothelial function (xanthine oxidase inhibition).

Leave How Gout can Kill You to read 21 Ways Gout Can Kill You.

Please Like GoutPal on Facebook
Please Share This Page

What do you think about this page?

Did this page help you? If yes, please consider a small donation. Your donations help keep GoutPal's gout support services free for everyone. Please click to donate:

If not, please tell me how I can improve it to help you more.

Please note that my Feedback Form does not yet work on the current version of this website. So please send your feedback:

Medical Disclaimer: The pupose of GoutPal is to provide jargon-free explanations of medical gout-related terms and procedures. Because gout sufferers need to know what questions to ask their doctor. Also, you need to understand what your doctor tells you. So this website explains gout science. But it is definitely NOT a substitute for medical advice.

Information on this website is provided by a fellow gout sufferer (Keith Taylor) with an accountant's precision for accurate data. But no medical qualifications. So you must seek professional medical advice about gout and any other health matters.

Google Gout

Type your question, or gout topic, in the search box. Or see Better Desktop Gout Search.