This fascinating look at white blood cells in action against uric acid crystals goes a long way to explaining the agony of gout. The fragmentation of white blood cells as they fight urate crystals attracts more white blood cells to join the battle leading to a vicious circle of inflammation causing yet more inflammation.
The title, in layman’s terms, means “Looking at inflammation from uric acid crystals with large white blood cells”
- Observations on phagocytosis of urate crystals by polymorphonuclear leucocytes.
- Rajan KT.
- Ann Rheum Dis. 1975 Feb;34(1):54-61.