Probenecid lowers uric acid by encouraging the kidneys to excrete more. It has many other effects on compounds passing through the body. This report explains that it reduces a protein that encourages inflammation – a second bonus for gout patients.
- Probenecid, a gout remedy, inhibits pannexin 1 channels.
- Silverman W, Locovei S, Dahl G.
- Am J Physiol Cell Physiol. 2008 Sep;295(3):C761-7.