Yesterday, I looked at quercetin for gout as a follow up to the potential gout natural remedies. I first looked at those foods around two years ago. I am trying to update the other compounds noted in that research, but there has been little development with cinnamon or orange.
However, I did find a report that I’d missed earlier. Going back to 2005, I found Xanthine Oxidase Activity in Vitro: Effects of Food Extracts and Components. This report has given me new insights into natural products for lowering uric acid.
I will do a complete review in the gout home remedy research guidelines, but I’d like to introduce the key points here.
Natural gout Remedies Report
Xanthine Oxidase Activity in Vitro: Effects of Food Extracts and Components looks at the inhibition or promotion of xanthine oxidase by several food items, and active compounds found in foods. Xanthine oxidase is the enzyme in our bodies that encourages purines to break down to uric acid. In pharmaceutical gout management, allopurinol and Uloric are the options for this type of inhibitor. In natural gout management, there are many compounds, often used in traditional medicines, that inhibit uric acid production in the same way. It is important to note that, though these natural compounds have the potential to lower uric acid in humans, the science here does not prove that these compounds will work. Inhibiting xanthine oxidase in the lab (in vitro) is one thing. Lowering uric acid in human gout patients (in vivo) is quite another.
There are two confounding factors, and if you understand these, they will help you take the right approach to natural gout remedies.
Food Extracts as Natural Gout Remedies
Before I look at the confounding factors, here is a list of foods that inhibit xanthine oxidase. The full report includes foods that promote xanthine oxidase or have no effect, and a list of single compounds. The following foods are listed in order of potency, with the most potent first within each group.
- Tea including Herbal Tea
- Black tea
- Rooibus (red bush) tea
- Raspberry leaf herbal
- Peppermint herbal
- Silver Needle white
- White Peony white
- Fruit & Vegetable Juices
- Purple Grape
- Water based Herb & Spice Extracts
Natural Gout Remedies Dosing
The first factor to prevent lab results applying to real life is the dose of active compounds. Apart from the difficulties of measuring the concentration of active ingredients at home, and preparing consistent treatment, there is another issue.
This report reveals that many natural compounds actually promote xanthine oxidase at low concentration. This phenomenon is also found in aspirin – low doses increase uric acid, whereas higher doses reduce it. The concentration cut-off varies from food item to food item, and I will explain this more in the detailed review.
Natural Gout Remedies Purity
The second factor to prevent lab results applying to real life is the quality of active compounds. This does not mean that manufacturing processes might compromise the quality of ingredients. It refers to the fact that some food items exhibit different properties from their main active compounds. Orange juice and grapefruit juice, for example, were shown to promote xanthine oxidase activity, yet a compound which is found in those juices, hesperetin, is a potent inhibitor. As the researchers explain, we must: “consider potentially beneficial dietary ingredients as a whole rather than on the activity of a single component.”
Natural gout Remedies: Next Steps
In my reviews of individual potential gout remedies, I will focus on whole food items, including extracted compounds only when they are readily available. Thus, you will not see much here on hesperetin, as it is not yet easy to buy outside the scientific community. Note that you should not confuse this with hesperidin which is a related compound that has little or no effect on uric acid.
As I said yesterday, the thing that matters most is how these potential natural gout remedies affect your uric acid. Self testing is easier if you own your own home uric acid test kit. However, if you get uric acid blood tests from your doctor, you can change supplements or the dose of supplements between each test to see if it helps uric acid. You should consult your doctor before experimenting with supplements or radical diet changes.
If you try any of these products, please share your uric acid test results in the gout forum.
Leave Natural Dose for Gout Remedy to browse the Gout Home Remedy guidelines.
Related Gout Facts: Gout Home Remedy
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