Orange Juice & Gout – Where’s The Proof?

There are a few studies related to orange juice & gout.

I have not seen a specific orange juice study on gout sufferers, but there is sufficient evidence to prove that orange juice lowers uric acid.

What we gout sufferers need is a specific study on gout patients to show what sort of daily intake is most effective.

If you are tired of lists of foods to avoid, orange juice has great potential for adding to your list of gout diet foods to eat. However, until we have some specific studies testing effects of orange juice on gout patients, I am not sure how strong a recommendation it deserves.

Orange Juice And Gout Study

The only investigation that is anywhere near a gout study is the Orange Juice and Gout study I reported last year. Unfortunately, this is a study on rats with induced gout.

To help us understand how we can improve our gout diet with orange juice, we need to see studies on confirmed gout patients. Even general population human studies would be more relevant, which brings me to…

Orange Juice And Uric Acid Studies

Orange Juice Antioxidant And Uric Acid

In 2003, a study into antioxidant properties of orange juice (Effect of orange juice intake on vitamin C concentrations and biomarkers of antioxidant status in humans) also measured uric acid.

12 non-gouty volunteers drank 500ml orange juice each day, split into a morning drink and an afternoon drink. After 14 days, the researches recorded significant increases in vitamin C, and they also note:

uric acid concentrations were lower when the vitamin C concentration was higher, and an inverse association was observed between uric acid concentrations and plasma vitamin C concentrations across time in both men and women

From that, it is tempting to dismiss orange juice in favor of vitamin C supplementation. However, subsequent studies have suggested other properties of orange juice that could have significant benefits for gout sufferers.

Orange Juice And Uric Acid Kidney Stones

Gout sufferers have a higher than normal risk for kidney stone formation. In 2006, a study investigated the potential for orange juice in the management of kidney stones (Comparative Value of Orange Juice versus Lemonade in Reducing Stone-Forming Risk).

13 volunteers drank 1200ml orange juice, split into 400ml 3 times a day with meals. During different phases of the experiment, orange juice was swapped for water or lemonade. Each drink was tested for a week, in random order. The orange juice phase consistently resulted in lower calculated undissociated uric acid, which lowers the risk for kidney stone formation.

Because an increase in urinary citrate and pH could provide protection against calcium and uric acid stone formation, orange juice but not lemonade potentially could play an important role in the management of recurrent nephrolithiasis [kidney stone formation] and may be considered an option in patients who are intolerant of potassium citrate.

Orange Juice, Blood Pressure And Uric Acid

In 2011, a study into blood pressure lowering properties of orange juice (Hesperidin contributes to the vascular protective effects of orange juice) also measured uric acid.

24 volunteers drank 500ml orange juice, split into breakfast and lunchtime. This was during one of three 4-week phases, being alternated with a control drink (22.5g sugar in 250ml water) plus hesperidin or a placebo. The researchers noted significant reduction in the concentration of uric acid after 4 week orange juice consumption.

After 4 wk consumption of orange juice, concentrations of uric acid in plasma were significantly lower than
after consumption of CDP [control drink of sugar water with placebo]

For the many thousands of readers who are also interested in blood pressure, I’m pleased to inform you that both orange juice and hesperidin reduced blood pressure

Orange Juice & Gout: Next Steps

As you see, there are strong indications that orange juice should be added to the guidelines for good gout foods to eat (or drink, in this case). However, without specific studies on actual gout patients, we do not know if conflicting factors might reduce its effectiveness.

As a safe gout diet component, there’s nothing to stop you trying your own experiments at home. Try alternating 500ml orange juice in your diet to replace some of your water intake. Test uric acid and compare 4 weeks of water against 4 weeks water with orange juice. Please share your results in the gout forums.

Leave Orange Juice & Gout to browse Gout Diet Foods To Eat guidelines

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Medical Disclaimer: The pupose of GoutPal is to provide jargon-free explanations of medical gout-related terms and procedures. Because gout sufferers need to know what questions to ask their doctor. Also, you need to understand what your doctor tells you. So this website explains gout science. But it is definitely NOT a substitute for medical advice.

Information on this website is provided by a fellow gout sufferer (Keith Taylor) with an accountant's precision for accurate data. But no medical qualifications. So you must seek professional medical advice about gout and any other health matters.

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