Uric Acid Causes Gout Pain
Everything you do as a gout sufferer affects how uric acid causes pain. Each part of the U-D-R-P process is affected in some way by food, exercise, age, gender, medication or environment factors. The details of how and why different factors affect different parts of U-D-R-P are scattered throughout the website. Each of those pages features a diagram showing which part of U-D-R-P it deals with. This page describes the overview of U-D-R-P. "And the point of this?" you may be asking. Read on... Clouds of GoutGout is a very complicated condition, and there are a lot of aspects that are not fully understood. Even the parts that are understood are often presented in a confusing way, or misrepresented. Don't get me wrong. Many people are happy with the advice and treatment they are receiving. If you are such a person, you need not worry too much about understanding U-D-R-P and how uric acid causes gout pain. But if, like me, you want to improve your quality of life without the misery of an overly restrictive regime, then you need to understand U-D-R-P.
U-D-R-P Overview
I have found it almost impossible to distinguish between pain caused by uric acid crystals forming, and pain caused by uric acid deposits dissolving. This makes it hard to be certain which lifestyle factors are improving gout, and which are making it worse. This becomes easier when you understand the U-D-R-P process. You just need to be careful, when changing your lifestyle that diet, exercise, medication etc all work together to affect how uric acid causes gout pain. Only change one factor at once, and do so gradually. Drastic change is almost certain to trigger gout pain because a dramatic change in concentrations of uric acid causes deposits to change. These changes to deposits cause reactions then pain. I have found that by gentle lifestyle and dietary changes I can gradually reduce the frequency and intensity of attacks. I realize that the only way to be free from gout is to reduce uric acid levels low enough and often enough to dissolve all deposits. You need to realize this, and understand U-D-R-P before you can manage gout. It doesn't matter which remedies and treatments you choose. Medications or alternatives can achieve a pain-free life and you must choose whichever suits you best.
Return from Uric Acid Causes Gout Pain to Explanations
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Uric acid is produced as a by-product of metabolism. In humans, there are no enzymes that break down uric acid further, so it must be excreted. Approximately two thirds is excreted through the kidneys in urine. Approximately one third is excreted through the bowel. Small quantities are also excreted in sweat and seminal fluid. The rate of excretion depends on several factors.
When the amount of uric acid dissolved in the blood rises above a certain level, it forms crystals that are deposited in the body. Conversely, when the uric acid level falls below a certain level, any existing crystals will start to dissolve. The certain level referred to above is known as the saturation point. The saturation point is different for everyone, and it changes according to certain factors, including temperature and blood pH level. Other factors, such as injury, can also trigger a change in body chemistry that cause uric acid to crystallize.
These deposits are usually in the joints which cause the swelling typically recognized as gout. Uric acid can also be deposited as tophi (the plural of tophus), a condition known as tophaceous gout. In the most painful cases deposits may form as kidney stones.
Crystals deposited as a result of high uric acid levels, do not directly cause pain. The crystals cause the immune system to react in the same way as it does to a viral or bacterial infection. When uric acid levels in the blood fall, crystals dissolve. This also causes an immune system reaction - more pain even when you are trying to fix your gout!
At the heart of most gout problems is the reaction of the body to deposits of crystals. Wherever the crystals form, the immune system attacks the crystals as they would a virus or other infection. Once the crystals are encased then the reaction stops, removing the cause of painful swelling. This is not the end however. The reaction, when applied to biological invaders, leads to the virus etc being killed thus removing the infection. With gout, the crystals are masked with a cell coating. When the crystals start dissolving, the coating is shed and the crystals are attacked by the immune system again.
The immune system reaction causes inflammation leading to pain. This is why anti-inflammatories are particularly effective against gout pain. Swiss scientists have recently discovered the specific cause of pain, giving hope that new pain blocking medicines will be developed in future.
Finally, we see how uric acid causes gout pain. Yet pain is still very misunderstood. Everybody tolerates different levels of pain, and different treatments affect people in different ways. There is a growing range of medical and alternative remedies for pain relief which I am constantly researching and adding to the website.