What is Probenecid?

Probenecid (sometimes referred to as Probenacid or Probenicid) is a drug that stimulates the kidneys to increase uric acid excretion.
This type of drug, known as a uricosuric, will cause the overall levels of uric acid in the blood to fall, thus reducing the chances of gout attacks in the long term.

However, in the short term, it can cause gout attacks as existing crystals re-dissolve.
For this reason, it is often prescribed along with a pain-relieving drug.

Probenecid will not normally prevent gout attacks until you have taken it for over 12 months.

Some people find they can stop taking it, once uric acid levels have been reduced and stabilized.
Regular uric acid tests will help to confirm your situation.
Note that you are at risk of contracting gout again if you stop taking the drug and have made no other lifestyle changes that reduce your gout risk.

Side-effects of Probenecid

As well as the short term risk of inducing gout flares, it can also cause kidney stones. You must drink plenty of water to counteract this. 10 to 12 large (8 ounce) glasses per day is the normal recommendation, but your doctor will advise you what is best for you. Some people experience upset stomachs, which can be treated with an antacid, such as Bicarbonate of Soda. As with all medicines you must consult your doctor immediately if you suffer any severe or prolonged side effects.

Is Probenecid for you?

Most people can tolerate this medication, but it should not be used by anyone with kidney problems. The drug has a significant, and not fully understood, impact on the way the kidneys work. Therefore you must be careful when taking other medicines at the same time. This includes non-prescription medications like aspirin. You must discuss any other medications you are taking with a qualified practitioner. If you do start taking it, you should not stop taking it during a gout attack. Your doctor can prescibe additional drugs to combat the pain of a gout attack, but if you stop it, you will lose the benefits of the drug almost immediately.

Return from Probenecid to Remedies for Gout

Probenecid Page Created: Before May 2008 - Last Reviewed: 17^th March 2009