Uric Acid: Antioxidant Protection For Heart, Cancer, Aging

Uric Acid: Antioxidant Protection For Heart, Cancer, Aging

Title
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.
Published
Nov 1981
Author(s)
Ames BN, Cathcart R, Schwiers E, Hochstein P.

Uric Acid investigation describing the valuable properties of urate as an antioxidant. Reports how uric acid fights against the toxic oxygen radicals that might be responsible for heart disease, cancer, and aging.

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Uric Acid & Evolution

Uric Acid & Evolution

Title
Loss of urate oxidase activity in hominoids and its evolutionary implications.
Author(s)
Oda M, Satta Y, Takenaka O, Takahata N.
Published
Mol Biol Evol. 2002 May;19(5):640-53.

Investigation of the genetic changes that caused humans to evolve without urate oxidase. Our lack of oxidase, present in most other animals, prevents uric acid breakdown. This gives us several advantages, with the disadvantage that if the levels of uric acid rise too high, gout and other diseases will affect us.

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Serum Urate And Recurrent Gout Attacks

Serum Urate And Recurrent Gout Attacks

A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy. Jun 2004. Shoji A et al. Gout study showing the relationship between persistent reduction of blood uric acid below the saturation point, and the reduction in frequency of acute gouty attacks.

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Serum Uric Acid In Acute Gout

Serum Uric Acid In Acute Gout

Serum uric acid in acute gout. Nov 1997. Logan JA et al. Gout study showing how uric acid often falls during an acute gout flare risking mis-diagnosis and poor patient management.

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Circadian Variation Uric Acid Elimination

Circadian Variation Uric Acid Elimination

Significance of circadian variations of uric acid
elimination. Sep 1983. B. D. Owen-Smith. Short article explaining that uric acid excretion is higher at night because uric acid production rises during sleep.

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Daily Uric Acid Excretion Variation

Daily Uric Acid Excretion Variation

On diurnal and nocturnal variations in the excretion of uric acid. Dec 1906. J. B. Leathes. Early study showing that uric acid excretion increases at night.

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Uric Acid, Gout & Hyperuricemia

Uric Acid, Gout & Hyperuricemia

Uric Acid

    Molecule

So very small

    So very cruel

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