UDRP:1 High Uric Acid Media

Febuxostat Briefing Material

Briefing Document for Febuxostat. Nov 2008. Takeda Pharmaceuticals North America, Inc. Comprehensive review of studies carried out to support the application for febuxostat, released under the brand name Uloric (Adenuric outside USA).

Milk Good For Gout - Soy Bad

Milk- and soy-protein ingestion: acute effect on serum uric acid concentration. Mar 1991, Garrel DR et al. The uricosuric effect of milk proteins reduce blood uric acid concentration, but with soy protein this effect is offset by the high purine levels.

Milk can be incorporated into your diet as part of your plan to beat gout. See the Gout Treatment section for other food-based gout cures.

Rasburicase (Elitek) Prescribing Information

US Prescribing information for rasburicase (brand name Elitek) supplied as a powder for intravenous use. This is only licensed for child and adult cancer patients with high uric acid from chemotherapy. Oct 2009

Morin: Uricosuric & Xanthine Oxidase Inhibitor

The Dual Actions of Morin (3,5,7,2′,4′-Pentahydroxyflavone) as a Hypouricemic Agent: Uricosuric Effect and Xanthine Oxidase Inhibitory Activity. Jan 2006, Zhifeng Yu et al. Morin, found in figs and other fruit, reduces uric acid in rats.

Morin from figs or mulberry tea, are examples of foods that can be used as uric acid lowering gout treatments. See the Gout Treatment section for other food-based gout cures.

Purine Metabolism

Purine Metabolism And Gout

The purine metabolism review is an in-depth analysis of how uric acid forms as a product of purine metabolism. This is not straightforward, as there are many different types of purines. Many common charts of foods high in uric acid list all purines as a total value. However, prompted by investigations and reviews such as this one, I have narrowed the list down to purine rich foods most likely to affect gout.

Metabolism Of Purines And Diet

The report also explains important nutritional aspects of the metabolism of purines, including results of experiments in the laboratory and in humans.

Purine Metabolism Review File Details

Purine and pyrimidine metabolism. Sep 1985 Zöllner. In-depth analysis of different sources of purines and uric acid, differentiating between endogenous purines, from body tissue, and exogenous purines, from diet. Reveals that allopurinol eliminates half of internally generated uric acid, and almost all dietary uric acid.

Vitamin C Reduces Uric Acid

The Effects of Vitamin C Supplementation on Serum Concentrations of Uric Acid. June 2005, Han-Yao Huang et al. Results of a Randomized Controlled Trial (RCT), showing that 500mg/day vitamin C for 2 months reduces blood uric acid, with better reductions for higher uric acid.

Vitamin C can help as a gout treatment, and there are other natural products that can be used as gout cures.

Vitamin C And Uric Acid

The investigation reveals a very important point about vitamin C and uric acid – the higher the starting point, the better the reduction. But even with the benefits of vitamin C, uric acid level is unlikely to drop enough for most gout sufferers.

The investigation breaks the subjects down to many different subgroups, with varying starting levels of uric acid in the blood. Though there are different absolute changes in uric acid, vitamin c achieves a fairly constant percentage reduction of around 10%. In this context, for effective treatment with vitamin c, uric acid needs to start at 5.5mg/dL (0.33mmol/L) for a 10% reduction to achieve a satisfactory target of 5mg/dL (0.30mmol/L). Of course, this might mean that, for higher starting levels of uric acid, vitamin C can make a contribution to a combination treatment program, but you must always get regular blood tests to make sure you stay in the safe zone.

Chart showing how the incidence of gout falls with lower uric acid.

This is used to illustrate the article Avoid Gout By Uric Acid Reduction, which is part of the Gout Treatment Reference Section describing the treatments that are available to lower uric acid.