Chart showing how low concentrations of pyrazinoate stimulate uric acid to be reabsorbed, whereas higher concentrations reduce re-absorption.

Diagram showing the effects of various substances on the re-absorption or clearance of urate within the kidney.

Diagram showing some of the genetic and external influences on the stimulation or inhibition of internal synthesiis of uric acid

40 30 30 Gout Diet

Ann Rheum Dis. 2000 Jul;59(7):539-43.

Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study.

Dessein PH, Shipton EA, Stanwix AE, Joffe BI, Ramokgadi J.

This report shows useful, though limited, blood uric acid reduction on a calorie controlled diet where nutrition is balanced to a 40:30:30 carbohydrate:protein:fats ratio.

To put this information in context, please see the Gout Diet Section.

Fasturtec

Product information for Fasturtec a brandname for rasburicase sold as Elitek in the USA. Contains interesting tables of outstanding uric acid reduction.

Serum Urate And Recurrent Gout Attacks

A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy. Jun 2004. Shoji A et al. Gout study showing the relationship between persistent reduction of blood uric acid below the saturation point, and the reduction in frequency of acute gouty attacks.

Treatment Failure Gout

Treatment failure gout. Nov 2009 Ali S, Lally EV. Describes some potential treatment options in refractory (unresponsive) gout. Reasons for treatment failure are:

1. Physician failure to diagnose and treat gout
2. Inadequate dosing of urate-lowering therapy
3. Allergy or intolerance to urate-lowering therapy
4. Allergy or intolerance to urate-lowering therapy
5. Lack of compliance with prescribed therapy

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